First, please confirm your configuration meets the following points:
Make sure your Trezor is running the latest firmware and you have the latest version of the MetaMask extension installed.
Also, make sure you have the latest version of Trezor Bridge, you should see “trezord” process running in your activity/system/task manager. If you cannot see the process running in the background, please try to reinstall it again. The latest version of Trezor Bridge can be downloaded from this source Trezor Suite
Use supported browsers only. Either Chrome or Firefox (try both and try using Incognito/privacy mode as well).
Clear your browser’s cache and make sure they are up to date.
Not only using a VPN, but also certain advanced Firewall or Antivirus settings, browser extensions (AdBlock, Privacy Badger, etc.), may cause these issues, therefore please try to disable them as well.
On top of that, use only one application/website/browser tab with Trezor at a time. It is possible that they are clashing with each other.